KMID : 1037120220400040561
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The World Journal of Men¡Çs Health 2022 Volume.40 No. 4 p.561 ~ p.569
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mRNA and Viral Vector COVID-19 Vaccines Do Not Affect Male Fertility: A Prospective Study
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Massarotti Claudia
Stigliani Sara Maccarini Elena Bovis Francesca Ferraro Mattia Francesco Gazzo Irene Anserini Paola Scaruffi Paola
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Abstract
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Purpose: To assess whether mRNA and viral vector coronavirus disease 2019 (COVID-19) vaccines detrimentally affected semen parameters.
Materials and Methods: In this prospective study, we enrolled 101 men vaccinated for COVID-19 (76% received mRNA vaccines, 20% viral vector vaccines, 2% a mixed formulation, and for 2 men no information about vaccine xlink:type was available) in 2021 and with a previous semen analysis. For each man we compared semen parameters before and after vaccination.
Results: Post-vaccine samples were obtained at a median of 2.3¡¾1.5 months after the second dose. After vaccination, the median sample volume significantly decreased (from 3.0 to 2.6 mL, p=0.036), whereas the median sperm concentration, the progressive motility, and total motile sperm count increased (from 25.0 to 43.0 million/mL, p<0.0001; from 50% to 56%, p=0.022; from 34.8 to 54.6 million, p<0.0001, respectively). Thirty-four patients were oligospermic before the vaccine, and also in these patients we observed a significant increase of sperm parameters after vaccine. Finally, we confirmed the aforementioned results in men who received a mRNA or a viral vector vaccine.
Conclusions: The semen parameters following COVID-19 vaccination did not reflect any causative detrimental effect from vaccination, and for the first time we demonstrated that this applies to both mRNA and viral-vector vaccines. The known individual variation in semen and the reduced abstinence time before the post-vaccine sample collection may explain the increases in sperm parameters.
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KEYWORD
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COVID-19, Infertility, male, Semen analysis, Vaccines, synthetic
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